Tumor-targeting efficacy of a BF211 prodrug through hydrolysis by fibroblast activation protein-α
نویسندگان
چکیده
منابع مشابه
Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts.
Murine studies have shown that immunologic targeting of the tumor vasculature, a key element of the tumor stroma, can lead to protective immunity in the absence of significant pathology. In the current study, we expand the scope of stroma-targeted immunotherapy to antigens expressed in tumor-associated fibroblasts, the predominant component of the stroma in most types of cancer. Mice were immun...
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Accumulated evidence has demonstrated that the microenvironment of a given tumor is important in determining its drug resistance, tumorigenesis, progression and metastasis. These microenvironments, like tumor cells, are vital targets for cancer therapy. The cross-talk between tumor cells and cancer-associated fibroblasts (CAFs, alternatively termed activated fibroblasts) is crucial in regulatin...
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BACKGROUND The tumor microenvironment plays a major role in multiple myelomas (MM). MM-BMSCs (bone marrow mesenchymal stromal cells) can support tumor growth and immune surveillance escape. On the other hand, fibroblast activation protein α, expressed by cancer stroma cells including BMSCs, has been shown to potentiate epithelial cancers growth and immune suppression. RESULTS MM-BMSC inhibite...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2017
ISSN: 1671-4083,1745-7254
DOI: 10.1038/aps.2017.121